Cancers | Free Full-Text | Phase I Dose Escalation Study with Expansion Cohort of the Addition of Nab-Paclitaxel to Capecitabine and Oxaliplatin (CapOx) as First-Line Treatment of Metastatic Esophagogastric Adenocarcinoma (ACTION Study)
A hybrid design for dose‐finding oncology clinical trials - Liao - 2022 - International Journal of Cancer - Wiley Online Library
Multi-stage dose expansion cohort (MSDEC) design with Bayesian stopping rule
On Biostatistics and Clinical Trials: Dose Limiting Toxicity (DLT) and Common Toxicity Criteria (CTC) / Common Terminology Criteria for Adverse Events (CTCAE)
Frontiers | A Dose-Finding Trial for Hyperthermic Intraperitoneal Cisplatin in Gynecological Cancer Patients Receiving Hyperthermic Intraperitoneal Chemotherapy
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) in Phase... | Download Table
Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials. - Abstract - Europe PMC
Determining drug dose in the era of targeted therapies: playing it (un)safe? | Blood Cancer Journal
Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis
Biostatistical intepretation series II Clinical Trials Phase I - mitigating misinterpretation risk in dose escalation studies
On Biostatistics and Clinical Trials: Dose Limiting Toxicity (DLT) and Common Toxicity Criteria (CTC) / Common Terminology Criteria for Adverse Events (CTCAE)
Dose levels, enrollment, and DLT in days 1-42 | Download Table
Recommended dosages in each arm. DLT, dose-limiting toxicity; RD,... | Download Scientific Diagram
Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial - ScienceDirect
Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial - eClinicalMedicine
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC
Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial | BMC Medical Research Methodology | Full Text
Principles of dose finding studies in cancer: a comparison of trial designs | Cancer Chemotherapy and Pharmacology
